Pharmacology
Zimax 250 mg belongs to the macrolide subclass of antibiotics known as azalide. In order to prevent microbial protein synthesis, Zimax 250 mg binds to the 50s ribosomal subunit of susceptible species. Moraxella catarrhalis, anaerobes such as Bacteroides fragilis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Haemophilus ducreyi, and Neisseria gonorrhoeae, as well as gram-positive and gram-negative bacteria such as Staphylococcus aureus, Streptoc Moreover, in vitro testing of Zimax 250 mg shown action against Campylobacter sp., Toxoplasma gondii, Treponema pallidum, Mycoplasma pneumoniae, Legionella pneumophila, and hominins.
Dosage of Zimax 250 mg
Adult: 500 mg once daily orally for 3 days or 500 mg once on day 1, then 250 mg once on days 2-5 for 4 days. For sexually transmitted diseases caused by Chlamydia trachomatis in adults, the dose is 1 gm given as a single dose or 500 mg once on day 1, followed by 250 mg once daily for next 2 days may also be given. Children: 10 mg/kg body weight once daily for 3 days for child over 6 months 200 mg (1 teaspoonful) for 3 days if body weight is 15-25 kg 300 mg (1½ teaspoonfuls) for 3 days if body weight is 26-35 kg; 400 mg (2 teaspoonfuls) for 3 days if body weight is 36-45 kg. In typhoid fever, 500 mg (21/2 teaspoonfuls) once daily for 7-10 days is given.
Administration of Zimax 250 mg
Procedure for reinstatement after suspension- Step 1: Thoroughly shake the bottle to break up the powder. Step 2: Fill the bottle with boiled and cooled water to the watermark on the label. Step 3: Mix the powder and water thoroughly to combine. Take Zimax 250 mg at least one hour before or two hours after eating.
Interaction of Zimax 250 mg
When food and antacids are present, Zimax 250 mg absorption is lessened. Due to the potential for ergotism brought on by an interaction between Zimax 250 mg and the cytochrome P-450 system, Zimax 250 mg should be avoided in patients who are receiving ergot alkaloids. With co-administration, care should be taken since macrolides raise the plasma levels of cyclosporin and digoxin. Warfarin, Theophylline, Carbamazepine, Methylprednisolone, or Cimetidine have not been found to interact with Zimax 250 mg.
Contraindications
Those who are hypersensitive to Zimax 250 mg or any other macrolide antibiotic should not take Zimax 250 mg. Ergot derivatives and Zimax 250 mg should not be administered together. Those with liver disorders should not use Zimax 250 mg.
Side Effects of Zimax 250 mg
Low-frequency side effects are experienced after taking Zimax 250 mg. A therapeutic withdrawal will reverse the adverse effects, which include nausea, vomiting, abdominal pain or cramps, flatulence, diarrhea, headaches, and skin rashes.
Pregnancy & Lactation
The Zimax 250 mg pregnancy category is B. Studies on animal reproduction have shown that Zimax 250 mg has no evidence of harming the fetus. Pregnant women have not been the subject of any good, controlled studies. Zimax 250 mg should only be used during pregnancy if no other suitable options are available, as research on animal reproduction are not always indicative of human response. The presence of Zimax 250 mg in breast milk is unknown. Hence, when giving Zimax 250 mg to nursing mothers, care should be taken.
Precautions & Warnings
It is advised to keep an eye out for any indications of superinfection with non-susceptible organisms, such as fungus when using any antibiotic. Those with renal impairment don't require a dose adjustment.
Overdose Effects of Zimax 250 mg
There is no information on Zimax 250 mg overdosage. Macrolide antibiotic overdose symptoms can include hearing loss, extreme nausea, vomiting, and diarrhea. The use of gastric lavage and other supportive treatments is advised.
Storage Conditions
Keep dry and away from heat and light. Keep out of children's reach.